Welcome to Medira Ltd, the company that specialises in a unique range of collagen biomaterials

Medira specialises in regenerative biomaterials.   Our mission is to delight clinicians, service provision leaders and patients alike with our unique range of natural, safe and highly effective biomaterials.

Whether stimulating healing from surrounding tissues with our collagen dressings, or using growth factors derived from our Tropocells Platelet Rich Plasma system, or a combination of both, regenerative biomaterials address the growing trend for a biological facilitation of wound healing.
Unlike natural materials, many synthetic advanced wound dressings, lack the functionality to promote a desirable biological response.

Collagen is available today in thousands of different products from skin creams to synthetic skin substitutes. It has been used safely and economically for many years in the health care field and is relatively easy to obtain today.

The predominant type of collagen in the health care arena is sourced from bovine. 
Medira is delighted to have a collagen biomaterial derived from a Piscean source.  A little known fact is that the amino acids hydroxyproline and proline, present in human Type I collagen, are also present in the Piscean Type I collagen molecule.
Medira's Piscean collagen dressings are highly biocompatible and immunogenic, removing all risk associated with bovine collagen. (Pati et al 2012)

Type I collagen from a Piscean source
A recently published paper provides the first scientific evidence from a pre-clinical setting using a porcine model, to explain how a Type I collagen dressing may improve wound closure by targeting multiple key mechanisms. (Elgharably 2013)

Findings show
  • Type I collagen served as a neutrophil chemotactic factor, recruiting large number of neutrophils to the wound
  • Increased macrophage infiltration
  • Significant increase in endothelial cell abundance
  • Cell receptors on the triple helix collagen molecule provide a scaffold for cellular attachment eg fibroblasts
  • Upregulation of collagen Type I gene expression and a significantly increased TypeI:III ratio – this could have significance for the tensile strength of the healed wound and scarring
  • Increased size of rete ridges demonstrating improved quality of closure  
These findings support the outcomes clinicians observe using the Type I dressing range.
Medira's unique range of Type I wound dressings have been listed on the 2013/2014 NHS High Impact Innovation catalogue, linked to the DOH Health, Wealth and Innovation Programme.



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Email: info@medira.co.uk

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